To make missiles have the ability to generate large overloads quickly when intercepting the high speed maneuvering targets, presents a dual control method of lateral thrust and aerodynamic force. This method can rapidly establish the angle of attack of missiles through a large attitude control moment. The influence of lateral thrust on overload response capability of missile is calculated using theoretical methods. The overload response capability of aerodynamic control and dual control is compared and analyzed. Simulation results show that it′s difficult to improve the response speed of the system by aerodynamic control. The overload response speed of the system can be improved significantly using the dual control of large attitude control moment, so as to achieve the optimal control effect.